Maximum residue levels for isopyrazam
- Food safety
- Pesticide MRLs
Summary
The European Union (EU) is withdrawing its 2024 proposal to amend the maximum residue levels (MRLs) for isopyrazam. The 2024 proposal has been withdrawn because the European Commission is now proposing a new approach to setting MRLs for pesticides that are not approved in the EU and that are categorised as highly hazardous for public health or the environment, such as isopyrazam (see Simplification of rules on pesticide MRLs and approvals).
EU withdraws proposal to amend isopyrazam MRLs.
Withdrawn Draft Commission Regulation amending Annexes II and III to Regulation (EC) No 396/2005 of the European Parliament and of the Council as regards maximum residue levels for isopyrazam in or on certain products
Draft Annex
Update
The European Union (EU) is withdrawing its 2024 proposal to amend the maximum residue levels (MRLs) for isopyrazam. The 2024 proposal has been withdrawn because the European Commission is now proposing a new approach to setting MRLs for pesticides that are not approved in the EU and that are categorised as highly hazardous for public health or the environment, such as isopyrazam (see Simplification of rules on pesticide MRLs and approvals).
What is changing?
The EU is withdrawing its 2024 proposal to reduce the MRLs for isopyrazam on certain products to the limit of determination (LOD, the lowest level that can be detected using the most modern and reliable analytical methods), except for those products for which MRLs are based on Codex MRLs (CXLs) or import tolerances that have been found to present no health risks for consumers. The European Commission informed the World Trade Organization Sanitary and Phytosanitary Measures (WTO SPS) Committee about this withdrawal in April 2026 (G/SPS/N/EU/762/Add.1).
Why?
The active substance isopyrazam is no longer approved in the EU because it has been classified as carcinogenic and toxic for reproduction (ECHA 2020). The EU initially proposed to reduce the MRLs for this substance to the limit of determination (LOD) on all products except those for which MRLs are based on Codex MRLs (CXLs) or import tolerances and found by EFSA (2021) to present no health risks for the consumer.
However, in December 2025 the European Commission proposed a new approach to MRLs for pesticides that are not approved in the EU and are categorised as highly hazardous for public health or the environment, reducing the MRLs for these substances on all products to the LOD. Isopyrazam is categorised by the ECHA as toxic for reproduction category 1B and therefore the 2024 proposal is no longer valid.
See Simplification of rules on pesticide MRLs and approvals.
Timeline
No timetable has been given for the development of a new MRL proposal for isopyrazam.
Background
MRLs are set in accordance with the rules set out in Regulation 396/2005. For information on current MRLs for other substances, please consult the EU Pesticide Residues database.
Resources
ECHA (2020) Opinion proposing harmonised classification and labelling at EU level of isopyrazam. European Chemicals Agency, Committee for Risk Assessment.
EFSA (2021) Review of the existing maximum residue levels for isopyrazam according to Article 12 of Regulation (EC) No 396/2005. EFSA Journal, 19(7): 6684.
Sources
Withdrawn Draft Commission Regulation as regards maximum residue levels for isopyrazam in or on certain products
Draft Annex
Tables & Figures
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EU withdraws proposal to amend isopyrazam MRLs.
Withdrawn Draft Commission Regulation as regards maximum residue levels for isopyrazam in or on certain products
Draft Annex
What is changing and why?
The European Union (EU) is withdrawing its 2024 proposal to amend the maximum residue levels (MRLs) for isopyrazam. That proposal reduced the MRLs to the limit of determination (LOD, the lowest level that can be detected using the most modern and reliable analytical methods), except for those products for which MRLs are based on Codex MRLs (CXLs) or import tolerances that have been found to present no health risks for consumers.
The 2024 proposal has been withdrawn because the European Commission is now proposing a new approach to setting MRLs for pesticides that are not approved in the EU and that are categorised as highly hazardous for public health or the environment, such as isopyrazam. See Simplification of rules on pesticide MRLs and approvals.
Timeline
No timetable has been given for the development of a new MRL proposal for isopyrazam.
Tables & Figures
Disclaimer: Under no circumstances shall COLEAD be liable for any loss, damage, liability or expense incurred or suffered that is claimed to have resulted from the use of information available on this website or any link to external sites. The use of the website is at the user’s sole risk and responsibility. This information platform was created and maintained with the financial support of the European Union. Its contents do not, however, reflect the views of the European Union.